TIDE

The immune system can eliminate tumors, but tumors express checkpoints that enable immune escape. Researchers conducted genome-scale in vivo CRISPR screens in eight murine cancer models treated with immune checkpoint blockade (ICB) to identify genetic drivers of immune evasion or sensitivity to anti-tumor immunity. This browser provides access to these data through a portal of interactive viz to probe how cancer evades the immune system. Using cross filtering and selections, the portal allows users to identify genes that increase or decrease the fitness of tumor cells growing in cell culture and/or growing as tumors in mice.